A Facile and Rapid Route for the Synthesis of New Heterocyclic Compounds with Thiohydantoins

Imidazo-fused heterocycles are used as anticancer agents. In this work, we describe the synthesis of the heterocyclic compound imidazothiazoles. The reaction of 5,5-diphenyl thiohydantoin derivatives with ethyl bromopyruvate at room temperature and in dichloromethane solvent to give the products 3a-e. The desired product under reflux in toluene solvent and in the presence of Para toluene sulfonic acid to give the compounds 4a-d. The structures of the new compounds were established by elemental analyses, IR, 1H NMR and 13C NMR data.

Keywords:

Imidazothiazoles , 5 , 5-Diphenyl thiohydantoin , Ethyl bromopyruvate , antibacterial