Determination of Phenylephrine by Nano Structure Electrochemical Sensor in Pharmaceutical Sample

In the present study, the glassy carbon electrode modified with sodium–dodecyl sulfate and multi wall carbon nanotubes and used for electrochemical oxidation study and determination ofphenylephrine by anodic stripping voltammetry. Phenylephrine is a drug used for nasal congestion, sinusitis, swelling of the mucous membrane ofthe nose, as well as medical eye examinations for dilation of the pupil. Phenylehrine can narrowcoronary heart also used to treat hypotension associated with anesthesia(1,2). This electrode constructed in room temperature. After the optimization of chemical and instrumental parameters, determination of phenylephrine was performed in phosphate buffer solution pH 5 inpharmaceutical sample and blood serum. The aim of this work is present of a simple and new sensor with wide linear range and low detection limit for determination of phenylephrine. This purposed sensor has a high sensitivity respect to other sensors. The obtained linear range and detection limit was 100nM to 25μM and 50nM respectively.

Keywords:

phenylephrine , sodium–dodecyl sulfate , carbon nanotubes