Warfarin sodium, 4-hydroxy-3-(3-oxo-1-phenyl-butyl) coumarin sodium, is a widely used anticoagulant drug prescribed to treat the blood clots (thrombosis) which can form in both thearteries and veins. The formation of thrombosis can be attributed to an induction of platelet adhesiveness, or an increase in the activation of clotting factors, such as prothrombin. Thrombosis can severely reduce or stop blood flow in the circulation, resulting in permanentdamage or death [1]. Warfarin sodium is an antagonist of Vitamin K, and inhibits the synthesis of prothrombin leading to a decrease in the ability of the blood to form clots [2]. The drug is almost completely bound to the surface of plasma proteins, principally albumin. It is biotransformedin the liver into inactive metabolites, which are excreted via the kidney with urine. Warfarin sodium usually detectable in the plasma within 1 h of oral administration and peakblood concentrations are reached within 2–4 h of administration [3]. Ionic liquids, which have been widely promoted as green and ‘designable’ solvents, are attracting considerable attention due to their chemical stability, low flammability, negligible vapor pressure, high ionicconductivity, and wide electrochemical window. Depending on their unique properties, ILs can be used in a wide variety of research fields, such as solvents for organic synthesis and polymerization reactions, catalysts, electrochemistry, and media for extraction processes [4].Polymeric nanoparticles have received increasing attention in both theoretical and applied research fields due to their potential applications as nanocarriers for catalysts, molecules with electronic and photonic functions, biological and medical species, drug carriers [5].In this paper,an electrochemical method for the determination of
warfarin at nanaocomposite of [Ni(CN)2(NH3] and poly[MImEO2BS] and nafion (NCPMNINGCE) film modified glassycarbon electrode (GCE) was presented by using cyclic differential pulse voltammetry. The electrochemical behavior of
warfarin was investigated with cyclic voltammetry. It has been found that the oxidation of
warfarin at the surface of modified electrode occurs at a potential ofabout 230 mV less positive than that of an unmodified carbon paste electrode,. (SWV) exhibits linear dynamic range from 1.0×10-6 to1.0×10-4 M and detection limits of 1.5×10-7 M for warfarin. The present method was applied to the determination of
warfarin in commercial pharmaceutical samples