Study of Kinetic Release and Taste Masked of a Novel Azithromycin Microcapsule Prepared by Spray-Drying Technique

Recent interest in the field of controlled drug delivery is increasing in medical sciences,chemistry, materials science, engineering, pharmaceutics,[1]. In this filed, kinetics studyingof drug release is important because kinetic models are the explanation of the fundamentalmass transport mechanisms; and the possibility to predict the effects of various factors on thedrug carrier designed; such as shape and size [2]. Azithromycin, as advanced-generation oferythromycin is highly lipophilic with poor water solubility and bitter tasting drugs whichmay be difficult to administer in an oral suspension [3]. The present investigation is aimed atuse of new taste-masking agent which obtains from the combination of polymers EudragitE100 and PEG 4000 to give highly efficient microencapsulated azithromycin by Spray-Drying Technique and study of kinetic model and mass transport mechanisms of theazithromycin release from microcapsules in different pH of buffer solution.