Application of statistical experimental design to the optimization of ultrasoundassisted dispersive solid-phase microextraction based on nanoparticles followed by spectrophotometry for the simultaneous determination of dyes in watersamples

Several auramine-O (AO) and malachite green (MG) methods separation andpreconcentration such as dispersive liquid– liquid microextraction (DLLME) cloud pointextraction (CPE), liquid–liquid extraction (LLE), solid-phase micro-extraction (SPE) anddispersive solid-phase micro-extraction (DSMPE) are also reported based on their ownadvantages and disadvantages amongst SPE procedures show remarks like simplicity,capability to eliminate undesirable matrix components which accelerate and candidate thistechnique for such propose at aforementioned level [1] . Nano-structure based adsorbent dueto their unique qualities like wide variety of interactions and high reactive sites are excellentextracting phases in solid phase extraction (SPE) and dispersive solid phase microextraction(DSPME) [2].