Investigation of Isoniazid release kinetic and mechanism relation with DEX-HEMA-PNIPAAm nanogels structure

Aim of this research is to find out the Isoniazid release kinetic. Degradable temperature sensitive Dex- HEMA-PNIPAAm nanogels which were synthesized by UV polymerization were loaded by Isoniazid. The Isoniazid release amounts taken from in vitro studies at two different temperatures, below and upper LCST, were mathematically modeled to investigate the kinetic of drug release. Mathematically inquiry of release phenomenon of Isoniazid makes it easy to predict and recognize the influence of delivery device laying out parameters on release kinetic formulation. The best fitted model showing the highest determination coefficient (R2) was Korsmeyer-Pepas which means predominant release mechanism is controlled by diffusion

Keywords:

kinetic , modeling , Isoniazid , nanogel , DEX-HEMA-PNIPAAm