Preparation and characterization of Fe3O4/SiO2/PVP for controlled release of drug

Magnetic drug delivery systems can be used in cancer treatment. In this study, magnetic nanocomposite hydrogels have been developed and demonstrated to be responsive to alternating magnetic fields. Fe3O4 nanoparticles were synthesized by co-precipitation method. The synthesized nanoparticles are modified by (3-aminopropyl)triethoxysilane (APTES) and coated with polyvinylpyrrolidone (PVP). Modified nanoparticles characterized by FTIR, SEM, XRD and magnetic properties are determined by vibrating sample magnetometer (VSM). The results indicate that PVP coated iron oxide nanoparticles are promising for magnetically targeted drug delivery

Keywords:

Fe3O4 , drug delivery , hydrogel , polyvinylpyrrolidone