OVERPRODUCTION STRATEGIES FOR MICROBIAL SECONDARY METABOLITES(QUORUM SENSING, ELICITATION( BASED ON MICROBIAL RESPONSE)

Secondary metabolites are organic compounds that are not directly involved in the normal growth, develop-ment or reproduction of an organism. Secondary metabolites often play an important role in defense systems of different organisms. Strategies for overproduction of microbial products can be based on microbial response, genetic engineering, metabolic engineering and ribosome engineering. Also molecular genetic improvement methods include amplification of SM biosynthetic genes, inactivation of competing pathways, disruption or am-plification of regulatory genes, manipulation of secretory mechanisms, expression of a convenient heterologous protein, combinatorial biosynthesis. Strategies for over- production of microbial products include Elicitors, quo-rum sensing. Elicitors, as stress factors, induce or enhance the biosynthesis of secondary metabolites added to a biological system. Quorum sensing is the communication between cells through the release of chemical signalswhen cell density reaches a threshold concentration

Keywords:

Overproduction , Secondary metabolites , Elicitors , Quorum sensing