Detection of breast cancer using non-invasive X-ray diffraction & XRF analysis of hair
Publish place: 12th International Congress on Breast Cancer
Publish Year: 1394
نوع سند: مقاله کنفرانسی
زبان: English
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ICBCMED12_092
تاریخ نمایه سازی: 2 تیر 1397
Abstract:
Introduction: An early diagnosis of breast cancer correlates directly on an accurate treatment plan and strategy. Early detection of breast cancer before its development would be a significant reduction of morbidity and mortality rates. Using hair samples to analysis the trace element concentrations is of interest among many researchers. X-ray fluorescence (XRF) and X-ray diffraction (XRD) are the most common methods in studying the structure and concentration of elements of tissues and also crystalline materials,using low energy X-ray. The aim of this study is to investigate application of X-ray diffraction & XRF analysis of hair in Detection of breast cancer Materials and Methods: Hair samples of 54 women (including 27 healthy and 27 patients) with average of 52.03 ± 11.44 years were analyzed. All the sample donors were Iranian women. For the measurements Wave Length X-ray Fluorescence (WLXRF) method was used. In this study, hair samples from 43 Iranian women (Age: 51.3 ± 11.5) had cut from occipital region of skull from healthy and also breast cancer patients women were analyzed using X-ray diffraction and the results were analyzed and were compared with mammography and pathology reports. Results: Trace elements in healthy individuals were higher than those in cancer patients. In addition, sensitivity of the used method (WLXRF) was 96% compared to mammography (77%) as a gold standard for breast cancer detection. Also The results showed a significant difference in height of 1st peak in WAXRD test of hair samples between healthy and patient group. In addition, sensitivity for purposed WAXRD method was 86% in comparison with synchrotron based XRD (64%) and mammography (70%). Conclusions: Trace elements in healthy individuals were higher than cancer patients and it seems that WLXRF may be used as a safe, low cost and reliable method with sensitivity higher than those of the other two relevant methods such as XRD and mammography. This study showed that the sensitivity of WideAngle X-ray diffraction (WAXRD) method on women hair samples of healthy and also breast cancer patients is comparable with mammography
Keywords:
Wave Length X-ray Fluorescence (WLXRF) , X-ray diffraction (XRD) , breast tissue , human hair , non-invasive
Authors
Asghar Maziar
Assistant Professor, Radiation Science department, School of allied medicine, Iran University of medical sciences, Tehran, Iran.
Daryoush Shahbazi-Gahrouei
Full Professor, Department of Medical Physics, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
Mohammad Bagher Tavakoli
Full Professor, Department of Medical Physics, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
Reza Reiazi
Assistant Professor ,Department of Medical Physics, School of Medicine, Iran University of medical sciences, Tehran, Iran