Select the Best Sperm for ICSI with DGC/Zeta procedure may Reduce Abortion Rate

Background: Implantation is a complex biological that is critical to successful pregnancy. Implantation failure is multifactorial in its origin and is a problem that is often unrecognized. One of these effectiveness factors is sperm quality. For this goal, a simple and non-invasive method of sperm selection, performed prior to ART procedures, should be developed. The Novel method DGC/Zeta appears to be a suitable procedure to recover sperm with normal chromatin and intact DNA. Therefore, we aimed to compare the pregnancy outcomes of DGC/ Zeta procedure with routine sperm selection (DGC), in infertile men candidate for ICSI. Methods: From a total of 100 ICSI cyclesstudied, 50 cycles were allocated to DGC/Zeta group and the remaining was included in the DGC group. Pregnancy outcomes were compared between the two groups. Results: In the present study, abortion rate significantly was lower in the DGC/Zeta group compared to the routine DGC method .As well as implantation and pregnancy rate were improved following the combined DGC/Zeta procedure when compared with DGC alone. Conclusion: Novel method DGC/Zeta may increase implantation rate and pregnancy outcome be due to use of strategy to select the best sperm or to eliminate those that are abnormal from the sperm population.  

Keywords:

Abortion , DGC , DGC/ Zeta , Implantation , Pregnancy