The Association of 4 STR Markers of PCOS1 Gene With Polycystic Ovary Syndrome

Background: Polycystic ovary syndrome (PCOS)is one of the most common endocrine disorders in women. This syndrome is a complex, heterogeneous disorder with unknown determined cause, but there is some strong evidence showingit can classified as a genetic disease. It has shown that PCOS1gene region is a good candidate to examine the risk of developing ovarian syndrome genetically. Methods: In this study, the polymorphism of 4 STR markers (D19S216, D19S905, D19S1183 and INSR) in this region- located in the short arm of chromosome 19- and the risk of developing PCOS in 110 women referred to Infertility treatment center of jihad daneshgahi of Qom province were done, using polymerase chain reaction techniques were discussed. Results: The results showed that allele 14 of D19S216 marker, allele 8 of D19S1183 marker and alleles 12 and 14 of INSR marker significantly increase the probability of developing PCOS (p≤0.05).;however none alleles of the D19S905 marker were significantly associated with the risk of PCOS. Hormonal investigations and demographic studies showed that fasting blood suger, body mass index, family history of PCOS in and blood group O+ are significantly different in two groups of patients and healthy participants (p≤0.05). Conclusion: There were an association between the polymorphism of 4 STR markers (D19S216, D19S905, D19S1183 and INSR of PCOS1 gene located in the short arm of chromosome 19 with the susceptibilityto PCOS in 110 women referred to Infertility treatment center of jihad daneshgahiof Qom

Keywords:

PCOS , STR marker , PCR