Role of L-Carnitine on Semen Parameter in Cimetidine Treated Adult Mice

Cimetidine is a drug widely use in the treatment of ulcer. Using of this drug for long period, cause dysfunction in the male reproductive system. Since L-carnitine has antioxidant effects potentially the purpose of this study is to investigate role L-carnitine in semen parameters in cimetidine treated adult mice. Twenty adult male mice NMRI were divided into four groups (n=5); control group received normal saline, we subdivided the test group into, 100 mg/kg cimetidine, 100 mg/kg L- carnitine , 100 mg/kg L- carnitine + 100 mg/kg cimetidine treated by injection peritoneum for 15 days. Sperm parameters were measured in groups. Cimetidine FDXVHG D VLJQLILFDQW (3 0.05) GHFUHD se in motility, viability and normal morphology, also did not affect on sperm count. L- carnitine caused a VLJQLILFDQW (3 0.05) LQFUHDVH sperm count , motility, viability and normal morphology. It is concluded that L- carnitine administration cause an improvement,gonadotoxic Cimetidine effects on sperm parameters in adult mice

Keywords:

Mice , Cimetidine , L- Carnitine , Sperm