The Effect Of Pheromone (Z)-9- Tricosene On Histological Parameters And The Spermatogenesis in Male Wistar Rat (Rattus Norvegicus)

The pheromones in urine, stool or skin glands have important roles in mammalian behavior especially reproductive-related ones that can be perceived through olfactory system and cause incitation of endocrine reaction and consequently behavioral responses. The purpose of present study was to evaluate the effect of different concentrations of pheromone (Z)-9-Tricosene on sexual hormones and parameters in male rat. The rats were maintained under natural conditions and were allocated into four groups, the three treatment and one control groups. The order of the 1ml injections in four defined groups was 100, 200 and 300 μg/kg of pheromone (Z)-9-Tricosene to each treatment groups, respectively besides distilled water for the control group. The statistical comparison of results between the four groups showed significant differences in the meannumber of spermatocytes and Leydig cells after treatment with pheromone (Z)-9-Tricosene (P<0.05). Also, the used different concentrations of pheromone (Z)-9-Tricosene affected the testosterone concentration significantly (P<0.05). The used pheromone did not affect the FSH and LH significantly, but there were significant changes in testosterone concentration (P<0.05). Therefore, (Z)-9-Tricosene can be a new candidate therapeutic compound in male fertility

Keywords:

Pheromone (Z)-9-Tricosene , Spermatogenesis , Sperm , Sexual Hormones