The Effect of a Single Mega dose Injection of Vitamin D on Blood Pressure in Mothers at First Gestational DiabetesMellitus: A Randomized Controlled Clinical Trial

Background: Health benefits of vitamin D has been proved by a large numberof studies, however, to the best of our knowledge there has been no studyinvestigating the effect of mega dose of vitamin D on gestational diabetesmellitus (GDM). This study was the first to assess the effect of postpartuminjection of mega dose of vitamin D on blood pressure (BP) in GDM. Methods:This is a randomized controlled clinical trial conducted on 58 pregnant womensuffering from GDM who were randomly assigned into control (CG, n = 24) andintervention group (IG, n = 24). Patients in intervention group (IG) received anintramuscular injection of 300,000 IU of vitamin D. BP, Serum concentration of25 (OH) D3, parathyroid hormone (PTH), calcium, phosphor, diastolic (DBP)and systolic blood pressure (SBP) were measured at the baseline and after 3months. Results: Mega dose supplementation resulted in increased serum25-hydroxy vitamin D concentrations in IG compared with the CG (62.10 nmol/lcompared with 24.10 nmol/l, P < 0.001). Additionally, injection of vitamin Dsignificantly reduced SBP (98.1 ± 9.0 mmHg compared with 106.9 ± 15.9mmHg, P = 0.02) and slightly decreased DBP but it was not statisticallysignificant (63.3 ± 1.5 mmHg compared with 73.6 ± 10.3 mmHg, P = 0.13).Serum PTH significantly decrease after intervention in IG compared with CG(2.88 ± 1.60 pmol/l compared with 4.78 ± 2.4 pmol/l P = 0.003). Conclusions:This study strongly improved vitamin D status in women with GDM andconsequently confirmed the efficacy of a mega dose of vitamin D injection ondecreasing of BP.

Keywords:

Gestational Diabetes Mellitus , Blood Pressure , Vitamin D