Locations of venous thrombosis in venous thromboembolism patients with and without thrombophilia

Introduction: Patients with thrombophilia mutations are at increased risk of developing deepvein thrombosis (DVT). On the other hand, some patients have DVT without thrombophilia.We investigated the location of DVT in patients with and without thrombophilia mutations.Methods: The location of DVT was investigated in 42 patients, 33 with and 9 withoutthrombophilia mutations in Hajar hospital, Shahrekord, Iran. Factor V Leiden, ProthrombinG20210, Methylene tetrahydrofolate reductase (MTHFR) C677T and PLA2 polymorphism ofplatelet glycoprotein IIb/IIIa were detected by polymerase chain reaction- restrictionfragment length polymorphism (PCR-RFLP). Data were analyzed using SPSS version 18.Results: 35.7% of patients had proximal and 64.3% distal DVT. FVL mutation was detectedin 2 patients with distal and 2 patients with proximal DVT. There was no case withProthrombin G20210 mutation among patients. 37% of patients with distal DVT had MTHFRC677T and 37% PLA2 polymorphism. 40% of patients with proximal DVT had MTHFRC677T and 20% PLA2 polymorphism. Patients without thrombophilia had more proximalthan distal DVT (26.6% versus 18.5%).Conclusion: DVT is more prevalent in carriers of thrombophilia than non carriers. Carriers ofPLA2 polymorphism have more increased risk of developing distal DVT than proximal.However, carriers of MTHFR C677T polymorphism had slightly more increased risk ofproximal DVT than distal. The type of thrombophilia polymorphism may impact the locationof thrombosis.

Locations of venous thrombosis in venous thromboembolism patients with and without thrombophilia Keywords:

Deep vein thrombosis , Thrombophilia , Distal DVT , Proximal DVT