Evaluation of Expression of P63 in Sputum Specimens of the Patients with Non Small Lung Cancer

Introduction:Lung cancer is the main cause of mortalities resulted from cancer. After prostate cancer in men and breast cancer in women this malignancy is the most prevalent type of cancer among human. Lung cancer is mostly diagnosed in its advanced stage and therefore its prognosis is often poor. The aforementioned studies stress the importance of expression of p63 in the tissue samples of different types of lung cancer. The aim of this research is the study of expression of P63 in the sputum samples of Non –Small Lung Cancer patients.Method:In a cross sectional descriptive analytical study which was carried out in the pathology department of Tabriz University of Medical Sciences on patients with lung cancer, the expression of P63 in the sputum samples of patients with non- small lung cancer was investigated.Results and conclusion:In this research, the expression of p63 in the sputum samples of 50 patients with Non –Small Lung Cancer cancer and 50 healthy individuals was examined and compared. The average age of Non –Small Lung Cancer patients and members of the control group was 63.20±15.01 and 62.04±12.50 years, respectively (P=0.676).The average expression of P63 in Non –Small Lung Cancer patients and control group participants was 32.40±19.98% and 2.48±4.09%, respectively.The average expression of P63 in Non –Small Lung Cancer patients significantly higher than the control group (P<0.001).Mean of P63 expression in patients with lung Squamous Cell Carcinoma(SCC) was %39.80±19.39, in pateints with Adenocarcinoma was %25±17.79, in patients with Atypical Carcinoid was%18±12.54 and in patients with undifferentiated Carcinoma was 60%.Mean expression of P63 was significantly higher in patients with lung SCC(P=0.010). Mean expression of P63 in patients with Well Differentiated SCC was significantly higher than in patients with Moderately Differentited SCC (P=0.018).

Evaluation of Expression of P63 in Sputum Specimens of the Patients with Non Small Lung Cancer Keywords:

Non Small Lung Cancer , P63 , Sputum , Immunohistochemical Staining