The evaluation of cholinesterase activity, fertility and oxidative stress parameters in men farmers in Karafs area of Hamadan

Objective: Infertility is one of the most important problems of human society, which its pattern is different in developing countries and developed countries. Organophosphorus compounds are the agents that their association with embryonic anomalies, reproductive processes has been proven. Regarding the prevalence of infertility in Hamadan Karafs region, in this study, changes in fertility and oxidative stress indices in sperm and serum samples of farmers were investigated.Material and Methods: In this study, thirty male infertile farmers and thirty healthy men were considered as the case and control groups, respectively. After sampling, changes in fertility and oxidative stress indices in sperm and serum samples were determined. Results: The findings indicated a significant reduction in cholinesterase activity in infertile farmers compared to healthy volunteers. In farmers, lipid peroxidation and serum testosterone levels significantly increased and total antioxidant capacity in serum and sperm as well as serum LH levels significantly decreased compared to control samples. In addition, spermiogram findings showed a significant decrease in the number, movement and progressive state of sperm cells in farmers. There was no difference in serum FSH levels, nitrite and the other sperm quality indices. Conclusion: Occurrence of oxidative stress and disorder of sexual hormones secretion may be associated with decreasing of semen quality and also infertility, in farmers of Karafs region, Hamadan, Iran.

Keywords:

Organophosphorus , Infertility , Oxidative stress