EFFECTS OF HYDROALCOHOLIC EXTRACTS OF CLOVES (SYZYGIUM AROMATICUM) ON SERUM BIOMARKERS, ANTIOXIDANT STATUS AND HISTOPATHOLOGICAL CHANGES OF KIDNEYS IN DIABETIC RATS

Background and Aim: The purpose of this study was to assess the possible impact hydroalcoholic extracts of Cloves (Syzygium aromaticum) on glucose status, lipid profile, and histopathological changes in kidneys of Diabetic Rats.Methods: Thirty-two rats (male) were distributed into 4 groups (n=8), including one group as healthy control and three diabetic groups. Streptozotocin was used for inducing diabetes (50 mg/kg). Diabetic rats were grouped into a control group (DC), diabetic treated with 4 mg/kg hydroalcoholic extract of Syzygium aromaticum (DSA), the DG group received 5 mg/kg glibenclamide. After the treatment period, rats’ blood samples were frozen at -70 °C for measuring glycemic indices, insulin, lipid profile, some oxidative stress markers and enzymes with antioxidant properties. The kidney was removed for histological study.Results: Control, DSA, and DG groups had significantly lower levels of FBS than the DC group (p<0.05); while levels of insulin were significantly lower in the DC, DSA, and DG groups than the control group (p<0.05); serum level s of urea and creatinine were statistically reduced in all groups other than DC group (P <.05); The levels of SOD, GPX, and were significantly increased in the DSA and DG as compared the DC group and also the serum levels of MDA was statistically decreased in the therapeutic groups. Syzygiumaromaticum showed antioxidant properties and protected the kidneys of the experimented rats from renal damages, resulting from diabetes.Conclusion: This study showed that Syzygium aromaticum may have beneficial effects in diabetes through improving glycemic control and lipid profile and preventing from diabetes-induced kidney damages.

Keywords:

Cloves , diabetes , lipid profile , antioxidant status , kidney damages