A novel ionically tagged magnetic nanoparticles as a reusable catalyst for synthesis of pyridines via anomeric based oxidation mechanism

N-heteroaromatic structures particularly pyridine ring systems are ubiquitous in pharmaceutical active molecules and natural products. Among the N-heteroaromaticmolecules, 2-amino-3-cyano pyridine scaffolds represent fascinating biological characteristics. These compounds can apply as A2A adenosine receptor antagonists, IKK-β inhibitors, inhibitors of HIV-1 integrase, anti-microbial, anti-tumour, analgesic, anti-inflammatory and antipyretic agents1-3. Herein, we designed a novel, green and reusable nanomagnetic catalyst, which was synthesized and the catalytic application of the titled catalyst was examined at the synthesis of pyridine derivatives via a four-component reaction (Figue 1). Resulting experimental data suggest that the final step of the plausible mechanism proceed via an anomeric based oxidation mechanism. The presented catalyst shows excellent potential of recycling and reusing at the described multicomponent reaction. The suggested mechanism for the above mentioned reaction will be presented.