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Title

Comparison of the Modified QuEChERS Method and the Conventional Method of Extraction in Forensic Medicine to Detect Methadone in Post-Mortem Urine by GCMS

Year: 1396
COI: JR_PJMT-6-3_002
Language: EnglishView: 209
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Authors

Seyed Majid Salimiasl - Department of Toxicology, Pharmaceutical Sciences Branch, Islamic Azad University, Tehran, Iran
Mohammad javad Khodayar - Department of Toxicology, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
Zahra Mousavi - Department of Pharmacology-Toxicology, Faculty of Pharmacy, Pharmaceutical Sciences Branch, Islamic Azad University,Tehran, Iran
Maryam Akhgari - Department of Forensic Toxicology, Legal Medicine Research Center, Legal Medicine Organization, Tehran, Iran

Abstract:

Background:Extraction of drugs is one of the biggest concerns and the most important part of preparation and determination in forensic medicine. The lack of an easy, efficient and fast extraction method is the most important and most difficult problem despite the development of forensic centers and their being equipped with new diagnostic devices. In the present study, a comparison was conducted between extraction of methadone in post-mortem urine (Autopsy), using modified QuEChERS method and conventional liquid-liquid extraction method in forensic medicine. Method: Methadone extraction from the Post-Mortem urine sample was performed using QuEChERS extraction method, which is a simple and fast micro-extraction method in tube. In this method, the analyte was extracted using MgSO4, NaCl salts and ethyl acetate solvent, and detected by Gas Chromatography-Mass Spectrometry (GCMS). Results: The recovery level of methadone analyte in the urine sample obtained was equal to 67% (N = 15) in QuEChERS method, and 49% (N =1 5) in LLE method. In this center, the LOD and LOQ of the methadone were determined, using GC-MS device, to be equal to 29.1ng/mL and 97ng/mL, respectively. According to the results obtained, there was a significant difference between QuEChERS and LLE methods, in terms of methadone test in post-mortem urine. Conclusion: Cheap, fast, effective, and green QuEChERS, improved with better recovery, could replace the LLE method in detecting methadone in Post-Mortem urine.

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How to cite this article: Salimiasl SM , Khodayar MJ , Mousavi Z , Akhgari M. Comparison of the Modified QuEChERS Method and the Conventional Method of Extraction in Forensic Medicine to Detect Methadone in Post-Mortem Urine by GCMS. Asia Pac J Med Toxi , 6(3):79-85

Paper COI Code

This Paper COI Code is JR_PJMT-6-3_002. Also You can use the following address to link to this article. This link is permanent and is used as an article registration confirmation in the Civilica reference:

https://civilica.com/doc/890613/

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Salimiasl, Seyed Majid and Khodayar, Mohammad javad and Mousavi, Zahra and Akhgari, Maryam,1396,Comparison of the Modified QuEChERS Method and the Conventional Method of Extraction in Forensic Medicine to Detect Methadone in Post-Mortem Urine by GCMS,https://civilica.com/doc/890613

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