In vivo assessment of a nanofibrous silk tube as nerve guide for sciatic nerve regeneration
Publish place: 1st International Iranian Tissue Engineering and Regenerative Medicine Congress (ITERM2018)
Publish Year: 1397
نوع سند: مقاله کنفرانسی
زبان: English
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شناسه ملی سند علمی:
ITERMED01_302
تاریخ نمایه سازی: 7 مرداد 1398
Abstract:
A nanofibrous silk nerve conduit has been evaluated for its efficiency based on the promotion of peripheral nerve regeneration in rats. The designed tubes with or without Schwann cells were implanted into a 10 mm gap in the sciatic nerves of the rats. Four months after the surgery, the regenerated nerves were monitored and evaluated by macroscopic assessments and histology. The results demonstrated that the nanofibrous grafts, especially in the presence of Schwann cells, enabled reconstruction of the rat sciatic nerve trunk with a restoration of nerve continuity and formation of nerve fibres with myelination. Histological data demonstrated the presence of Schwann and glial cells in regenerated nerves. This study strongly supports the feasibility of using artificial nerve grafts for peripheral nerve regeneration by bridging large defects in a rat model.
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Authors
Maryam Ebrahimi
Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine , Tehran University of Medical Sciences , Tehran , Iran
Jafar Ai
Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine , Tehran University of Medical Sciences , Tehran , Iran
Esmaeil Biazar
Department of Biomaterials Engineering, Tonekabon Branch, Islamic Azad University, Tonekabon, Iran
Somayeh Ebrahimi-Barough
Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine , Tehran University of Medical Sciences , Tehran , Iran