Optimized oocyte numbers

The main goal of any assisted reproductive tecnique is having live birth of an healty child. Today the measure of success in IVF must be the Cumulative Live Birth rate (CLB) per started cycle. The ability to predict the ovary response is the priority to obtain the right number of oocytes and to define the right individual treatment for the right patients. Although the number of the oocytes retrieved is poorly correlated to the quality and to the competence of the oocytes, but if we have more eggs (> 15), we increases the chance to obtain a baby. Indeed, the woman age is the only fact affecting embryo quality. Many factors can be use as predictors of ovarian response: age, biochemical parameters (FSH and AMH), morphological parameters (antra follicular count) but also some clinical conditions like polycystic ovary syndrome (PCOS) and low BMI. AMH and AFC may be considered a very good predictors of the hyper or hypo response. In according to ovarian reserve we can individualize four main categories of patients: high responder, normal responder, moderate/low responders and poor responders. For each group we can have different treatment strategies and different objectives.