Frequency and comparison of seroepidemiology HSV and CMV in women with natural childbirth and abortion in Shahid Beheshti Hospital in Abadan, Iran

Background and Aim: The purpose of this study was to determine the seroprevalence of herpes simplex virus type 1 (HSV-1), type 2 (HSV-2) and CMV antibody in pregnant women admitting to antenatal care clinic of Shahid Beheshti Hospital in Abadan, Iran. Materials and Methods: Serum samples were collected in during the study. The enzyme-linked immunosorbent assay was used to detect anti-HSV-1, anti-HSV-2 type and anti- CMV. Socio-demographic and obstetric characteristics were used for further study. Results: Between January and December 2016, we have studied 325 pregnant women referred to Shahid Beheshti Hospital. The mean ages of womens were 27.66 ± 5.96 years old (range 16 to 43 years). Of the 325 participants in this study, 40 (12.3 %) were HSV-1 seropositive, 78 (24%) were HSV-2 seropositive and 36 (11%) were CMV seropositive. A combined analysis was performed for HSV-1 and HSV-2: the percentages of individuals testing both HSV-1 and HSV-2 negative, both HSV-1 and HSV-2 positive, were 207 (63.7%) and 4 (1.2%) respectively. Conclusion: In summary, this study shows a relatively low proportion of pregnant women in our region are exposed to HSV and CMV infection than another part of Iran. CMV and HSV screening of pregnant women and their neonates can play a role in decreasing congenital infection and its severe consequences.

Keywords:

Herpes simplex virus type 1 and type 2 , Cytomegalovirus , Pregnancy , Neonatal herpes