Context: Emotional disturbances are caused by various factors that include two general biological and cognitive components. Understanding the factors affecting emotional disturbances is important in improving the quality of life of individuals. Aims: This study was aimed to determine the mediation role of acceptance and
mindfulness in relation between behavioral inhibition/activation system sensitivity and emotional distress of Islamic Azad University, Tabriz branch. Settings and Design: The research method of the study was descriptive form type of correlational. Subjects and Methods: The statistical population of the study included all students of the Islamic Azad University, Tabriz branch. Among them, 380 participants (190 females and 190 males) were selected through cluster random sampling. To collect the data, Carver and White’s (1994)behavioral inhibition and behavioral activation scales, Bond et al. ’s (2007) second version of the
Acceptance and Action Questionnaire‑II, and Bauer et al.’s (2006) five‑facet
mindfulness questionnaire and depression, anxiety, and
stress scale, were used. Statistical Analysis Used: To analyze the data, the Pearson correlation coefficient and multiple regression were used. Results: The findings indicated that behavioral inhibition/ activation systems, acceptance, and
mindfulness could significantly predict about 45% of
depression variance, 53% of
anxiety variance, and 41% of
stress variance of emotional distress. Conclusions: According to the findings, it could be concluded that stress, anxiety, and
depression as emotional distress are the result of the behavioral inhibition/activation systems that they are the result of the acceptance and
mindfulness effect. Infact, the acceptance and
mindfulness have the mediation role in relation between behavioral inhibition/activation system sensitivity and emotional distress. In order to regulate emotions, it should be pay attention to behavioral inhibition/activation systems, acceptance, and mindfulness.