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Title

The Effect of Galantamine on Liver Function in Hepatic Ischemia/Reperfusion Injury in Rats

مجله بیماری و تشخیص، دوره: 8، شماره: 1
Year: 1398
COI: JR_IEJM-8-1_006
Language: EnglishView: 252
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Authors

Majid Askaripour - Department of Physiology, School of Medicine, Bam University of Medical Sciences, Bam, Iran.
Javad Jamshidian - Department of Basic Sciences, School of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran.
Seyed Reza Fatemi Tabatabaei - Department of Basic Sciences, School of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran.

Abstract:

Background: Hepatic ischemia-reperfusion (IR) injury may affect different biological and functional roles of the liver. The present study aims to evaluate the effects of galantamine as a cholinergic agent on the acute and late phases of IR. Materials and Methods: Forty rats were randomly allocated to eight groups (n=5): IR groups weresubjected to 90 min ischemia followed by 4 and 24 hours reperfusion to induce acute and late phases of IR, respectively, two groups received pre- or post-treatment dose(s) of galantamine in the acute phase of IR, two groups received pre- or post-treatment dose(s) of galantamine in late phase of IR, and two sham-operated groups. Blood samples were taken, and ALT, AST, ALP, and LDH were measured to evaluate the liver function. Result: Pre-ischemic treatment with galantamine decreased the levels of ALT, AST, and ALP in the acute phase of IR, unlike the late phase (P-value<0.05). Post-ischemic treatment with galantamine in the acute phase of IR was decreased all enzymes (P-value<0.05). Unlike the latter, treatment with galantamine in the late phase of IR was increased these values. Conclusion: We concluded that pre- and post-ischemic treatment with galantamine could be ameliorated hepatic IR injury, in the acute phase versus the late phase, which should be further studied in detail

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This Paper COI Code is JR_IEJM-8-1_006. Also You can use the following address to link to this article. This link is permanent and is used as an article registration confirmation in the Civilica reference:

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Askaripour, Majid and Jamshidian, Javad and Fatemi Tabatabaei, Seyed Reza,1398,The Effect of Galantamine on Liver Function in Hepatic Ischemia/Reperfusion Injury in Rats,https://civilica.com/doc/992012

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Type of center: علوم پزشکی
Paper count: 129
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