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Title

Midazolam Induced Learning and Memory Impairment Is Modulated by Cannabinoid CB1 Receptor Agonist and Antagonist

Year: 1395
COI: JR_SBMU-1-1_007
Language: EnglishView: 289
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Authors

Abdolaziz Ronaghi - Neuroscience Research Center & Department of Physiology, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Saeedeh Karamzadeh - Department of Pharmacology and Toxicology, Pharmaceutical Sciences Branch and Pharmaceutical Sciences Research Centre, Islamic Azad University, Tehran, Iran
Sahar Jowkar - Neuroscience Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Zahra Mousavi - Department of Pharmacology and Toxicology, Pharmaceutical Sciences Branch and Pharmaceutical Sciences Research Centre, Islamic Azad University, Tehran, Iran
Nima Naderi - Neuroscience Research Center & School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Abstract:

Background: Memory impairment is a well-known effect of many benzodiazepine compounds which is mediated through their action on gamma-aminobutyric acid type A (GABAA) receptors. On the other hand, cannabinoids can affect learning and memory process through presynaptic modulation of the release of both excitatory glutamate and inhibitory GABA transmitters in brain regions involved in learning and memory. The aim of the present study was to investigate the effect of cannabinoids on memory impairment and long-term potentiation (LTP) reduction properties of the short acting benzodiazepine midazolam.Materials and Methods: One week after insertion of guide cannula by stereotaxic surgery, cannabinoid compounds or midazolam were administered by intracerebroventricular (i.c.v.) injection into lateral ventricle of male rats. Spatial memory task was evaluated using Morris water maze (MWM) test. Electrophysiological evaluation was done by field potential recording of hippocampal neurons in unconscious rats.Results: In MWM test, while i.c.v. administration of AM251 (200 and 500 ng) per se could not change learning and memory function in rats, pretreatment of rats with AM251 (500 ng; i.c.v.) attenuated midazolam-induced memory impairment. In field potential recording, while i.c.v. administration of AM251 (500 ng) and WIN55212-2 (10 μg) did not have any effect on population spike amplitude, pretreatment of rats with both AM251 and WIN55212-2 significantly diminished midazolam-induced PS amplitude reduction in hippocampal neurons.Conclusion: OurOur results suggest the involvement of cannabinoid CB1 receptors in both memory impairment and LTP reduction in hippocampal neurons which was produced by midazolam. This interaction is likely through their effect on both GABAergic and glutamatergic receptors in hippocampus.

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This Paper COI Code is JR_SBMU-1-1_007. Also You can use the following address to link to this article. This link is permanent and is used as an article registration confirmation in the Civilica reference:

https://civilica.com/doc/994777/

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Ronaghi, Abdolaziz and Karamzadeh, Saeedeh and Jowkar, Sahar and Mousavi, Zahra and Naderi, Nima,1395,Midazolam Induced Learning and Memory Impairment Is Modulated by Cannabinoid CB1 Receptor Agonist and Antagonist,https://civilica.com/doc/994777

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Type of center: علوم پزشکی
Paper count: 5,527
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