HN-02410266_Effect of Wheat Germ-Enriched Enteral Formula on Clinical and Anthropometric Factors in Mechanically Ventilated Patients Admitted to TheIntensive Care Unit

Introduction: To evaluate the effect of a wheat germ-enriched formula from the first day of admission until weaning from the ventilator in patients admitted to the intensive care unit (ICU).Methods: This randomized controlled clinical trial study conducted on 100 patients admitted to the ICU of Imam Khomeini Hospital, Iran. Patients were randomly divided into two groups to intake wheat germ-enriched formula or standard formula from the first day of admission until weaning from the ventilator. Duration of mechanical ventilation, length of ICU and hospital admission, body composition, mortality rate, Sequential Organ Failure Assessment (SOFA), and Glasgow Coma Scale (GCS) scores before and after the intervention were compared between the two groups.Results: Wheat germ-enriched formula caused a significant reduction in the length of mechanical ventilation, ICU length of stay, and SOFA score compared to the control group (p<0.001). Also, the intervention group demonstrated a significant increase in basal metabolic rate (BMR), arm circumference, skeletal muscle mass (SMM), body cell mass (BCM), and GCS score compared to the control group (p<0.05). There was no significant difference between the two groups in terms of hospital length of stay, ICU mortality, and body fat percentage (p> 0.05).Conclusion: Results revealed that the wheat germ-enriched formula can exert beneficial effects on clinical and anthropometric variables in patients admitted to the ICU.

Keywords:

Wheat germ , enteral formula , mechanical ventilation , ICU , clinical trial