Loading of Chlorhexidine into theHKUST-1 MOF and EvaluatingTheir Antibacterial Performance

Microbial infection is one of the issues that humans have faced it for many years. Recently special attention has been paid to Metal-organic frameworks (MOFs) in biomedicine [1]. MOFs can be used as controlled delivery platforms for bioactive metal ions and molecules by encapsulating them in their pores or use them as a part of their structures[2]. HKUST-1 is a kind of MOFs that was made from benzene-1,3,5-tricarboxylate (BTC) and copper ion[3]. Chlorhexidine (CHX) is a disinfectant agent and haswidely applications in fighting bacteria [4]. Previouslyseparate use of HKUST-1 and chlorhexidine in the field of antibacterial activity has been carried out [5,6]. In this work,the chlorhexidine was loaded onHKUST-1 and antibacterial activity was studied. Various methods were employed to characterize structures and the successful loading of the chlorhexidine in HKUST-1. Antibacterial activity was evaluated by agar well diffusion test and MIC test.In this way two main bacteria with names Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli) were used.The results showed that antibacterial activity was improved and the synergy effect was also found in [e-mail] important result was that the release of Antibacterial agents (chlorhexidine and Cu2+ ions) became controlled.