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The effect of Calcium dobesilate on anxiety and physical power in a mice model of aging

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Year: 2019
COI code: SRCCG05_089
Paper Language: English

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Authors The effect of Calcium dobesilate on anxiety and physical power in a mice model of aging

  Elham Hakimizadeh - Physiology-Pharmacology Research Center, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
  Iman Fatemi - Research Center for Tropical and Infectious Diseases, Kerman University of Medical Sciences, Kerman, Iran
  Ayat Kaeidi - Physiology-Pharmacology Research Center, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
  Jalal Hassanshahi - Physiology-Pharmacology Research Center, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, Iran

Abstract:

Calcium dobesilate CaD reduces the vascular permeability in diabetic retinopathy. CaD has a wide range of pharmacological effects such as anti-inflammatory and antioxidant. In the current study, the neuroprotective properties of CaD in aging mice induced by D-galactose D-Gal were assessed. For this purpose, we used twenty-eight male mice. CaD 50 and 100 mg/kg/p.o. , was administrated daily in D-gal-treated 500 mg/kg/p.o. mice for six weeks. Different behavioral tests were examined after drug administration. The brain activities of superoxide dismutase SOD , glutathione peroxidase GPx were determined. To determine the brain damage, histopathological alterations in hippocampus were assessed by hematoxylin and eosin H&E staining. Our results indicated that behavioral changes in animals under study can be attenuated by CaD. We also found that CaD increased the SOD and GPx in aging mice brain. Moreover, histopathological evaluations of the brain confirmed these results. These data provide novel insights that CaD has protective effects on behavioral manifestation in aging model mice through ameliorative effects on oxidative stress parameters

Keywords:

Aging; Calcium dobesilate; Oxidative stress; Mice.

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Hakimizadeh, Elham; Iman Fatemi; Ayat Kaeidi & Jalal Hassanshahi, 2019, The effect of Calcium dobesilate on anxiety and physical power in a mice model of aging, 5th congress of student research committee of rafsanjan university of medical sciences, رفسنجان, دانشگاه علوم پزشكي رفسنجان, https://www.civilica.com/Paper-SRCCG05-SRCCG05_089.htmlInside the text, wherever referred to or an achievement of this article is mentioned, after mentioning the article, inside the parental, the following specifications are written.
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Type: Medical University
Paper No.: 288
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