Synthesis of dipyrazolo-1,4-dihydropyridine in the presence of a novel deep eutectic system

Dipyrazolopyridine are one of the most widely used organic compounds that have been used as high-Luminescent dyes, Nichrome diodes and anti-inflammaory, antiviral and antitumor druges. These compoundes have been synthesized from condensation of hydrazine, aldehyde, β-ketoester and ammonium acetate. Previously, p-TSA,1 nano-ovalbumin,2 nano-CdZr4(PO4)63 and nano-CuCr2O44 have been used for promotion of this procedures.Deep eutectic solvents (DES) are generally composed of two or three cheap and safe components which are capable of associating with each other, through hydrogen bond interactions, to form a eutectic mixture5. The resulting DES is characterized by a melting point lower than that of each individual component. From the view point of green chemistry, these DESs are even more attractive since some of them have been proven to be biodegradable and compatible with enzymes further increasing their interest. in this work, we have prepared a novel deep eutectic system from sodium acetate and triethanol amine (TEA) with low melting point and used it for synthesis of dipyrazolopyridine under microwave conditions (Fig. 1).

Keywords:

Deep eutectic system , Dipyrazolo-1 , 4-dihydropyridine , Multicomponent reaction