Regioselective synthesis of new 5H,10H-dipyrimido[2,1-b:4',5'-d][1,3]thiazine as a novel heterocyclic system
Publish place: 27th Iranian Seminar on Organic Chemistry
Publish Year: 1398
نوع سند: مقاله کنفرانسی
زبان: English
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شناسه ملی سند علمی:
ISOC27_183
تاریخ نمایه سازی: 19 اسفند 1399
Abstract:
Pyrimidothiazines are a class of heterocyclic compounds that have been described as corrosion inhibitor for carbon steel in 1.0 M HCl, Filament temperature sensitive protein Z (FtsZ) inhibitors, 15-LO inhibitory activities, anti-inflammatory and antipyretic.1 The main synthetic methods for the formation of various bicyclic pyrimidothiazines involve the reaction of pyrimidine-2-thiones with urea, 1,2-epoxy-3-chloropropane, 3-bromopropanoic acid derivatives, acetylene dicarboxylates or DMF-DMA and carbon disulfide.2 In view of these observations and in continuation of our studies on developing the new routes for the synthesis of various fused heterocyclic derivatives containing pyrimidine core,3 herein we report a simple and efficient method for the synthesis of new fused dipyrimido[2,1-b:4',5'-d][1,3]thiazines as a novel heterocyclic system. In addition, we present our findings on the regiochemistry of the reaction by performing x-ray analysis.
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Authors
Toktam Afrough,
Department of Chemistry, Faculty of Science, Ferdowsi University of Mashhad, ۹۱۷۷۵-۱۴۳۶ Mashhad, Iran
Mehdi Bakavoli,
Department of Chemistry, Faculty of Science, Ferdowsi University of Mashhad, ۹۱۷۷۵-۱۴۳۶ Mashhad, Iran
Hossein Eshghi
Department of Chemistry, Faculty of Science, Ferdowsi University of Mashhad, ۹۱۷۷۵-۱۴۳۶ Mashhad, Iran