Synthesis, characterization and catalytic evaluation of Fe3O4@SiO2-propyl@L-proline for the synthesis of novel derivatives of benzo[d]imidazoles

Compounds with imidazole nucleus are a common and important substructures found in natural products and pharmacologically active compounds. They act as glucagon receptor antagonists, inhibitors of P38 MAP kinase, β-Raf kinase, transforming growth factor b1(TGF-b1) type 1 activin receptor-like kinase (ALK5), cyclooxygenase-2 (COX-2), CB1 cannabinoid receptor antagonists, modulators of P-glycoprotein (P-gp)-mediated multidrug resistance (MDR), biosynthesis of interleukin-1 (IL-1) 1. There are a lot of reports for the synthesis of benzoimidazoles but they suffer from some serious defects, such as tedious workup and purification, significant amounts of toxic waste materials, highly acidic conditions, long reaction time, occurrence of side reactions, low yields, use of expensive reagents or catalysts, low selectivity and high temperatures in refluxing or microwave condition. Therefore, development of easy, green, effective, high yielding, and eco-friendly approaches using novel catalysts for the synthesis of imidazoles is an important.In continuation of our previous work 2, herein, we specifically address the synthesis and usage of Fe3O4@SiO2-propyl@L-proline magnetic nanoparticle as catalyst for the synthesis of new generation of benzo[d]imidazoles (Scheme 1). All of organic compounds are new and characterized by IR, 1H NMR, 13C NMR, Mass and elemental analysis.

Keywords:

Green Chemistry , Fe3O4@SiO2-propyl@L-proline , benzo[d]imidazoles