One-pot Synthesis of the pyrimido[4,5-d]quinolones derivatives using methanesulfonic acid

Uracil is an important component of nucleic acids and one of the five nucleobases. Its molecules can act as nucleophiles and electrophiles. [1] Uracil is an important component in helping enzymes carry out different reactions and the making of polysaccharides. Uracils are very common in natural products. 6-Aminouracils are used as raw materials for the synthesis of heterocyclic frameworks of biological significance. Recent literature shows 6-aminouracil derivatives leading to advancement in procedures of various already known reactions.[2],[3]In a reaction vessel,a mixture of 6-aminouracil(1mmol),aldehyde(1mmol),2-hydroxynaphthalene 1,4dione(1mmol) in the presence of Methanesulfonic acid (MSA) In H2O/ETOH for 2hr afforded the pyrimido[4,5-d]quinolones. after complecction of the reaction as followed by TLC . the reaction mixture was cooled to room temperature and then poured in to cold water. The solid product was filtered and washed with boiling water to give the pure product in excellent yield.[4]

Keywords:

Multicomponent reactions , 6-aminouracil , aromatic aldehyde , 2-hydroxynaphthalene 1 , 4dione.