Arylation of electron-deficient double bonds through metal-catalyzed reactions

It has been quite a while that synthesis of organic frameworks through metal-mediated reactions has gained organic chemists’ attention.1 The underlying reason behind their wide application is that transition metals possess a special aptitude for C–H bond activation which facilitates practical and economical functionalization of organic molecules.2Among all procedures being put forth in this area, molecules having to leave groups which produce only gaseous waste are highly satisfactory since they are in accordance with Green Chemistry postulates.3 Thus, due to the superb attribute of these starting materials, we set our mind to take advantage of these substances and functionalize electron-deficient heterocycles by the aid of transition metals as promoters. The obtained moieties due to having double bonds in their building blocks can have wide applications ranging from biology to the materials sciences.

Keywords:

Arylation , Carbon-carbon bond formation , C-H activation