Synthesis, separation, purification and characterization of novel nano-derivatives of azo-compound thiazolidine dione

Thiazolidine-2,4-dione (TZD) is an important heterocyclic ring system that exhibits a range of pharmacological activities, but not limited to, including anti-hyperglycemic, anti-cancer, anti-inflammatory, anti-arthritic, and anti-microbial, etc 1-3. Among them, anti-hyperglycemic is the widely studied effect of TZD derivatives that has also been extended to the development of clinically used ‘glitazone’ drugs such as rosiglitazone lobeglitazone, pioglitazone, and troglitazone, etc 4-6. In this study, a new nano-derivatives of phenyldiazenyl benzylidene thiazolidine-2,4-dione for the first time was prepared from premade azo-compound and thiazolidine dione and further was connected via alkyl-linkage on nanoparticles of gold, silver and copper to improve pharmaceutical effectiveness.

Keywords:

Thiazolidine-2 , 4-dione (TZD) , Glitazone , Azo-compound , Nano-derivatives of phenyldiazenyl benzylidene thiazolidine-2 , 4-dione