pH-sensitive Fe3O4@SiO2@ CH2=CHSiH3 magnetic nanocarrier for targeted anti cancer drug delivery labeled with carboxymethylcyclodextrin(CM-β-CD) and folic acid

Applications of Fe3O4 nanoparticles in the field of biotechnology involve targeted drug delivery,1 magnetic resonance imaging (MRI),2 contrast enhancement and hyperthermia reagents, biophotonics,3 and detection, diagnosis, and magnetic field–assisted radiation treatment of cancerous cells 4. In present research a qualified nanocarrier for targeted drug delivery to tumor cells based on magnetic mesoporous silica nanoparticles (MMSNs), consisting of Fe3O4 core coated with mesoporous silica and a pH-responsive shell of amino acid L-cystien conjugated carboxymethyl-B-cyclodextrin and folic acid was prepared (Fig.1). Doxorubicin (DOX) an anticancer drug was introduced into nanocarier spheres. The nanoparticles were characterized using various scanning electron microscope (SEM), Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD) thermogravimetric analysis (TGA), and vibrating sample magnetometer (VSM).

Keywords:

Nanocomposites , Targeted drug delivery , Anti-cancer , Magnetic nanocarrier , Amino acid