The convenient one-pot synthesis of 2,3-dihydroquinazolin-4(1H)-ones catalyzed by novel, green and recoverable MCM-41-CPTMS-DMG-Cu nanocatalyst

2,3-Dihydroquinazolinone derivatives are heterocyclic compounds with nitrogen atoms molecules that have been reported to possess a wide range of various pharmacological1 and biological properties, antifertility, antibacterial, antitumor, antibiotic, analgesic, antihistaminic activities 2. Not surprisingly, numerous efforts have already been made in direct preparation of quinazolinone3. the development of simple, efficient, clean, high yielding and environmentally friendly approaches using new catalysts for the synthesis of these compounds is an important task for organic chemists.In this study, Ni-dimethylglyoxime complex supported onto organically modified MCM-41 was prepared and used as an efficient, heterogeneous, recoverable and thermally stable nanocatalyst for the one-pot synthesis of 2,3-dihydroquinazolin-4(1H)- ones from 2-aminobenzamide and aromatic aldehydes in ethanol solvent and under reflux conditions. This heterogeneous nanocatalyst was characterized using FT-IR, SEM, EDS, XRD, TGA and ICP techniques. The catalyst showed good recyclability and can be reused for at least six sequential cycles without significant loss of its catalytic activity.

Keywords:

Nickel-dimethylglyoxime complex , MCM-41 , Nanocatalyst , 2 , 3- Dihydroquinazolin-4(1H)-one