Atrp Fabricated dual sensitive based on pPDMAEMA-PCL-S-S-PCL-pPDMAEMA Triblock Copolymers for cancer targeting cells

ATRP or atom transfer radical addition is one of the most often used synthetic polymerization methods to prepare well-define polymers with complex architecture. 1 functional copolymers prepared by ATRP were used for cancer targeting. 2 Herein, we report the synthesis of pPDMAEMA-PCL-S-S-PCL-pPDMAEMA Triblock Copolymers in three steps as shown in Figure 1. In the first step, Bis(2-hydroxyethyl) disulfide prepared from oxidation of 2-mercaptoethanol in ETAC in presence of NaI and 30% H2O2. 3 In the second step, HO-PCL-ss-PCL-OH was synthesized by ring opening polymerization of ε-caprolactone using cystamine as initiator and tin (II) 2-ethylhexanoate as catalyst . In the third step, pPDMAEMA-PCL-ss-PCL-pPDMAEMA polymers were synthesized using ATRP. The viscous crude solution was purified by precipitation in cold diethyl ether twice and was characterized with IR and 1H NMR

Keywords:

ATRP , Bis(2-hydroxy ethyl) disulfide , ring opening polymerization , poly caprolacton , macroinitiator ,