Effect of qurcetin liposomes on main brain antioxidative enzymes and motor activity under acute low-dose diazinon exposure in male rats

There are many reports that show the effects of diazinon (DZN) on behavioral disorders. In this study possible acute oxidative neurotoxicity was induced with single dose of DZN ۱۰ mg/Kg for ۲۴ hours in male rats. Behavioral experiments of rats on the elevated plus maze (EPM) were investigated following DZN and/or the pegilated liposomes (QPEGL) ۲۰ mg/kg treatment after ۲۴ hours. Animals were decapitated, brains removed, and frozen at -۸۰. The brain superoxide dismutase (SOD), and glutathione peroxidase (GPx) levels were determined. In the EPM results, the ratio of the number of entries to the open arm to the total entries (total entries to the open arms and the close arms) and the time spent in the open arm to the total time of the total entries decreased in the DZN group than the control one no differently (p > ۰.۰۵), these parameters were increased in the QPEGL+ DZN group and Q + DZN group compared to the control (p > ۰.۰۵). SOD and GPx parameters have no significant difference compared to the DZN and the control groups, although improved in the QPEGL+ DZN group than the DZN one (p > ۰.۰۵). In this study, we concluded that low-level DZN exposure for the short term has no significant effect on the main brain antioxidative enzymes although it generally affects motor activity and the QPEGL has an ameliorative effect on them.

Keywords:

Antioxidative enzymes , Diazinon , Motor activity , Quercetin liposomes