The Effect of Regular Swimming Exercise on the Levels of Renal Matrix Mettaloproteinase-۲ and Transforming Growth Factor-β۱ in Rats with Diabetes

Masoumeh Habibian; Mohammad Reza Saghafi; Parvin Farzanegi

The Effect of Regular Swimming Exercise on the Levels of Renal Matrix Mettaloproteinase-2 and Transforming Growth Factor-β1 in Rats with Diabetes

Publish place: Journal of Kerman University of Medical Sciences، Vol: 23، Issue: 4

Publish Year: 1395

Type: Journal paper

Language: English

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https://civilica.com/doc/1583258

Document National Code:

JR_JKMU-23-4_004

Index date: 9 January 2023

The Effect of Regular Swimming Exercise on the Levels of Renal Matrix Mettaloproteinase-2 and Transforming Growth Factor-β1 in Rats with Diabetes abstract

Background & Aims: Numerous studies have reported the renoprotective effects of exercise in both human and animal models of diabetic nephropathy. However, detailed mechanism of action by which exercise has a favorable influence on renal fibrogenic factors is not yet fully understood. Therefore, the aim of this study was to assess the effect of swimming exercise on the activity of renal matrix mettaloproteinase-2 (MMP-2) and transforming growth factor-β1 (TGF- β1) in rats with diabetes. Methods: The study sample consisted of 28 male Wistar rats that were randomly divided into 4 groups (7 rats per group) of control, diabetes, exercise, and diabetes-exercise. Diabetes was induced through an intraperitoneal injection of alloxan (90 mg/kg) in rats. The animals received swimming exercise for 6-30 minutes per day, 5 days a week for 8 weeks. The rats were sacrificed 72 hours after the last treatments and renal MMP-2 activity and TGF- β1 level were evaluated by Zymography and ELIZA (enzyme-linked immunosorbent assay) method. Data were analyzed using one-way analysis of variance. Results: Diabetes induction significantly increased renal TGF-β1 (P < 0.001) and decreased MMP-2 activity (P < 0.001) compared with the control group. Furthermore, 8 weeks of swimming exercise was associated with a significant decrease in renal TGF-β1 level (P = 0.001) and elevated MMP-2 activity (P = 0.001) in rats in the diabetes-exercise group. Conclusion: It seems that the renoprotective effects of regular swimming exercise against diabetes-induced kidney damage may be partly mediated via the up-regulation of renal MMP-2 activity and reduction of TGF-β1 level in diabetic renal tissue.

The Effect of Regular Swimming Exercise on the Levels of Renal Matrix Mettaloproteinase-2 and Transforming Growth Factor-β1 in Rats with Diabetes Keywords:

Swimming exercise , Diabetes , Transforming growth factor-β1 , Matrix mettaloproteinase-2

The Effect of Regular Swimming Exercise on the Levels of Renal Matrix Mettaloproteinase-2 and Transforming Growth Factor-β1 in Rats with Diabetes authors

Masoumeh Habibian

Assistant Professor, Department of Physical Education and Sports Sciences, Faculty of Human Sciences, Qaem Shahr Branch, Islamic Azad University, Qaem Shahr, Iran

Mohammad Reza Saghafi

Department of Exercise Physiology, Faculty of Human Sciences, Sari Branch, Islamic Azad University, Sari, Iran

Parvin Farzanegi

Associate Professor, Department of Exercise Physiology, Faculty of Human Sciences, Sari Branch, Islamic Azad University, Sari, Iran

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