Reversing the Warburg effect to control cancer: a review of diet-based solutions
Publish Year: 1401
Type: Journal paper
Language: English
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Document National Code:
JR_JCOMS-2-3_001
Index date: 19 July 2023
Reversing the Warburg effect to control cancer: a review of diet-based solutions abstract
Warburg effect is a form of cellular metabolism commonly used by cancer cells, in which, consumption of glucose and production of acidic cell metabolic wastes take place at a considerably higher rate. The effect is well described in the literature, however, the applications for cancer prevention and treatment have not been resolved effectively yet. According to the Warburg effect, anaerobic cellular respiration and the resulting acidic cellular environment are linked to the development of cancerous tumors. But an oxygen-rich environment with optimum alkalinity at the cellular level can result in retaining healthy cells and inhibiting cancer cell growth. As an alternative or complementary solution for cancer treatment based on the Warburg effect, a healthy balanced diet with alkalizing (but not alkaline) properties helps maintain acid-base balance in the body and also provides optimum metabolic rate and sufficient hydration for more effective health improvement. This paper presents a review of the key concepts related to links between cancer and dietary and environmental factors, with the main focus on the Warburg effect and energy metabolisms in cancer cells. In addition, some practical diet-based solutions are summarized that may potentially control cancer by utilizing the reversed Warburg effect by which, optimum pH levels and sufficient oxygenation may be provided at the cellular level.
Reversing the Warburg effect to control cancer: a review of diet-based solutions Keywords:
Reversing the Warburg effect to control cancer: a review of diet-based solutions authors
Hassan Bahrami
Independent Health/Nutrition Researcher
Majid Tafrihi
Molecular and Cell Biology Research Laboratory, Department of Molecular and Cell Biology, Faculty of Sciences, University of Mazandaran, Babolsar, Iran
Soraya Mohamadzadeh
Department of Biology, Faculty of Science, University of Zanjan, Iran