Precision of C-reactive protein in the diagnosis of acute appendicitis
Publish place: Social Determinants of Health، Vol: 8، Issue: 1
Publish Year: 1401
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_JSDI-8-1_013
تاریخ نمایه سازی: 28 تیر 1402
Abstract:
Background: Appendicitis is known as inflammation in the appendix, and its treatment is
merely through surgery. There is mistaken diagnosis according to clinical presentations. Creactive
protein is an annular pentameric protein found in blood plasma, whose circulating
concentrations rise in response to inflammation. It is an acute-phase protein of hepatic origin.
Therefore, the aim of this study was to evaluate the diagnostic effect of C-Reactive Protein
(CRP) in the diagnosis of acute appendicitis in patients referring to Valiasr Hospital in
Qaemshahr city, Iran in ۲۰۱۷-۲۰۱۸.
Methods: This study was a diagnostic study and blood samples were collected from patients
with acute abdomen pain with suspected appendicitis in Qaemshahr Valiasr Hospital. Then
CRP results were compared with pathological results as golden standard; then sensitivity,
specificity, positive predictive value (PPV), and negative predictive value (NPV) of this test
were determined based on standardized test (pathologic result).
Results: The sensitivity and specificity of CRP test in diagnosis of acute appendicitis were
۷۱.۴۲% and ۶۰.۵۸%, respectively. In addition, PPV and NPV were ۸۸.۸۸% and ۴۲.۸۵%,
respectively.
Conclusion: According to the results of this study, CRP can be considered as one of the
predictive tests of acute appendicitis. Evaluation of CRP levels, alongside with other diagnostic
approaches, can be used as an adjunctive diagnostic method in the diagnosis of acute
appendicitis.
Keywords:
Authors
Melody Omranniava
Medical Sciences College Sari Branch, Islamic Azad University, Sari, Iran
Shaghayedh Javan
Sari Branch, Islamic Azad University, Sari, Iran
Ghahraman Mahmodi
Hospital Administration Research Center, Sari Branch, Islamic Azad University, Sari, Iran