Investigating the effect of exercise on P۵۳ gene expression in breast cancer patients

One of the most common cancers in men is breast cancer, which leads to the death of many patients every year. The suppressor protein P۵۳ is one of the indicators whose high levels in the serum of people with cancer lead to a decrease in the growth rate of cancer cells. There is evidence that exercise can alter P۵۳ levels. Therefore, the present study was conducted with the aim of investigating the effect of resistance training on P۵۳ gene expression in breast cancer patients. In this study, a randomized clinical trial, ۴۰ men aged ۵۰ to ۶۵ with breast cancer were randomly selected and divided into two control and intervention groups (combined aerobic-resistance exercises). The comparison between two groups was done using independent t-test and by SPSS version ۲۴ software. The results showed that after ۸ weeks of resistance training, there is a significant difference between the serum levels of P۵۳ suppressor protein in the two groups (P-value ≥۰.۰۵). Based on the results of the present study, it can be said that resistance training increases the serum levels of P۵۳ suppressor protein in patients with breast cancer and thus controls and helps in the treatment of this cancer

Keywords:

breast cancer , resistance physical activity , clinical trial.