Susceptibility pattern of Candida albicans isolated from Iranian patients to antifungal agents

Publish Year: 1395
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:

JR_CUMM-2-1_005

تاریخ نمایه سازی: 11 آذر 1402

Abstract:

Background and Purpose: Candidiasis is a major fungal infection, and Candida albicans is the major cause of infections in humans. The Clinical and Laboratory Standards Institute (CLSI) developed new breakpoints for antifungal agents against C. albicans. In this multi-center study, we aimed to determine the drug susceptibility profile of C. albicans, isolated from Iranian population according to new species-specific CLSI. Materials and Methods: Clinical samples were cultured on Sabouraud dextrose agar and were incubated at room temperature for seven days. The isolates were transferred to Professor Alborzi Clinical Microbiology Research Center, Shiraz, Iran. C. albicans were identified by using API ۲۰C AUX system. Broth microdilution method was used to determine the minimum inhibitory concentrations (MICs) of amphotericin B, caspofungin, voriconazole, fluconazole, posaconazole, itraconazole, and ketoconazole, based on CLSI document M۲۷-S۴ and new breakpoints for some azoles and caspofungin. Results: Overall, ۳۹۷ C. albicans were isolated from patients admitted to ten university hospitals in Iran. The MIC۹۰ of the isolates to amphotericin B, caspofungin, voriconazole, fluconazole, posaconazole, itraconazole, and ketoconazole were ۰.۱۲۵, ۰.۱۲۵, ۰.۱۲۵, ۱, ۰.۰۶۴, ۰.۵, and ۰.۱۲۵ μg/ml, and rates of resistance were ۰.۵%, ۰.۳%, ۳.۸%, ۲.۸%, and ۲.۵% for amphotericin B, caspofungin, voriconazole, fluconazole, and itraconazole, respectively. Conclusion: According to our data, fluconazole is the drug of choice for management of patients at risk for systemic candidiasis throughout the region, since it is cost-effective with low side effects.

Authors

Parisa Badiee

Professor, Alborzi Clinical Microbiology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

Hamid Badali

Department of Medical Mycology and Parasitology, Invasive Fungi Research Centre (IFRC), School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran

Kambiz Diba

Cellular and Molecular Research Center, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran

Abdolkarim Ghadimi Moghadam

Department of Pediatrics, Yasuj University of Medical Sciences, Yasuj, Iran

Ali Hosseininasab

Department of Pediatrics, Kerman University of Medical Sciences, Kerman, Iran

Hadis Jafarian

Professor Alborzi Clinical Microbiology Research Center, Nemazi Hospital, Zand Ave., Shiraz, Iran

Rasoul Mohammadi

Department of Medical Parasitology and Mycology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Hossein Mirhendi

Department of Medical Mycology and Parasitology, School of Public Health and Institute of Health Research, Tehran University of Medical Sciences, Tehran, Iran

Mohammad Javad Najafzadeh

Department of Parasitology and Mycology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Ahmad Shamsizadeh

Jundishapur Infectious and Tropical Diseases Research Centre, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

Jafar Soltani

Department of Pediatrics, Besat Tertiary Hospital, Kurdistan University of Medical Sciences, Sanandaj, Iran