Clinical and Paraclinical Characteristics of COVID-۱۹ Patients: A Systematic Review and Meta-Analysis

Publish Year: 1400
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:

JR_TBSRJ-4-1_006

تاریخ نمایه سازی: 11 آذر 1402

Abstract:

Introduction: Recently, a new strain of coronaviruses, which originated from Wuhan City, Hubei Province, China has been identified. According to the high prevalence of new coronavirus, further investigation on the clinical and paraclinical features of this disease seems essential. Hence, we carried out this systematic review and meta-analysis to figure out the unknown features. Material and Methods: This study was performed using databases of Web of Science, Scopus and PubMed. We considered English cross-sectional and case-series papers which reported clinical, radiological, and laboratory characteristics of patients with COVID-۱۹. We used STATA v.۱۱ and random effect model for data analysis. Results: In the present meta-analysis, ۳۲ papers including ۴۹۵۰۴ COVID-۱۹ patients were studied. The most common clinical symptoms were fever (۸۴%), cough (۶۵%) and fatigue (۴۲%), respectively. The most common radiological and paraclinical features were bilateral pneumonia (۶۱%), ground-glass opacity (۵۰%), thrombocytopenia (۳۶%) and lymphocytopenia (۳۴%). The study also showed that the frequency of comorbidities and early symptoms was higher in critically severe patients. Moreover, we found the overall mortality rate of three percent. Conclusion: According to that there are many cases without Computed Tomography Scan findings or clear clinical symptoms, it is recommended to use other confirming methods such RNA sequencing in order to identification of suspicious undiagnosed patients. Moreover, while there is no access to clinical and paraclinical facilities in in public places such as airports and border crossings, it is recommended to consider factors such as fever, cough, sputum and fatigue.

Authors

Keyvan Heydari

Student Research Committee, School of Medicine, Gastrointestinal Cancer Research Center, Mazandaran University of Medical Sciences, Sari, Iran.

Parisa Lotfi

Student Research Committee, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.

Nima Shadmehri

Science Department, University of Tehran, Tehran, Iran

Mohammad Yousefi

Department of Medicine, School of Medicine, Semnan University of Medical Sciences, Semnan, Iran.

Maedeh Raei

School of Medicine, Sari Branch, Islamic Azad University, Sari, Iran.

Pouya Houshmand

School of Veterinary Medicine, University of Tehran, Tehran, Iran.

Mohammad Zahedi

Department of Medical Biotechnology, Student Research Committee, School of Allied Medicine, Iran University of Medical Sciences, Tehran, Iran.

Reza Alizadeh-Navaei

Gastrointestinal Cancer Research Center, Non-communicable diseases institute, Mazandaran University of Medical Sciences, Sari, Iran.

Sahar Bathaeian

Influenza Research Lab, Department of Virology, Pasteur Institute of Iran, Tehran, Iran.

Sahar Rismantab

Ramsar Campus, Mazandaran University of Medical Sciences, Ramsar, Iran.

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