Vaccine Design Based on Live Attenuated Cells of Toxoplasma gondii: a Review

Toxoplasma gondii is well- known as a common parasite with high proliferative activity in the nucleated cells. This parasite has infected nearly one third of the people worldwide. Infection can result in chorioretinitis in immunocompetent hosts, encephalitis in HIV/AIDS positive patients and abortion and neonatal loss in congenital toxoplasmosis. Development of vaccines for toxoplasmosis infection is very important for decreasing infection transmission routes of the disease in various host species in the world. Live attenuated vaccines are closest to a natural infection; therefore, they are good rescuers of the immune system and often create lifelong immunity with only one or two doses. In this study, the researchers reviewed the current status in the development of live attenuated vaccines on Toxoplasma infection.

Keywords:

Toxoplasma gondii , vaccine , Tachyzoite , Bradyzoite