Investigating the effect of carbendazim poison on elastase enzyme using Thermal Stability, FTIR and docking methods
Publish place: The fourth international conference on research findings in basic sciences and engineering sciences
Publish Year: 1402
نوع سند: مقاله کنفرانسی
زبان: English
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شناسه ملی سند علمی:
ENGCONGE04_002
تاریخ نمایه سازی: 8 بهمن 1402
Abstract:
Carbendazim is a systemic fungicide with the molecular formula C۹H۹N۳O۲. This type of fungicide is used to control and treat diseases caused by fungi on vegetables, fruits and various types of plants. Carbendazim causes infection in humans through routes such as mouth, skin, and inhalation and it is considered an environmental pollutant .In fact, the components resulting from the decomposition of this compound, for example, amino bezimidazole, limit cell division by acting on microtubules.And as a result, reproductive damage or fertility disorders are created. Elastase is a glycoprotein enzyme that belongs to the serine proteases family, which breaks down peptide bonds. It is secreted from the endocrine gland of the pancreas and is one of the proteases that catalyze the breakdown of elastin protein, a component of connective tissue.In a recent study, the effect of carbendazim on elastase enzyme was investigated using FTIR and TM spectroscopy. The results showed that carbendazim makes the elastase enzyme more unstable and also affects its secondary structure.
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Authors
Mahbubeh Abdellahi
Student , Department of Biology Biology, Shahrekord University University, ShahrekordShahrekord, Iran
Sadegh Farhadian
Assistant Professor,Department of Biology Biology, Shahrekord University University, ShahrekordShahrekord, Iran
Behzad Shareghi
Full Profesor, Department of Biology Biology, Shahrekord University University, ShahrekordShahrekord, Iran