Mediastinal and Chest Wall Masses in Children:A Single Institution Study
Publish place: IRANIAN JOURNAL of PATHOLOGY، Vol: 1، Issue: 4
Publish Year: 1385
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_IJP-1-4_005
تاریخ نمایه سازی: 5 آبان 1393
Abstract:
Background and Objective: Mediastinal masses in children are a heterogenous group of asymptomatic potentially life-threatening congenital, infectious, or neoplastic lesions that presentcomplex diagnostic and therapeutic dilemmas. Materials and Methods: The clinical and laboratory features of 65 patients who had openbiopsies in Ali-Asghar hospital over 11 years were reviewed. Results: Seventy-two percent of cases were male and 28% were female. The age variedbetween 2.5 months and 19 years. Eighty-four percent of lesions were malignant and 16% were benign. Neurogenic tumors were the most common (36.9%). In order of frequency the following lesions were the most common neuroblastoma (mostly in posterior mediastinum), Hodgkin’sand non-Hodgkin’s lymphoma (mostly in middle mediastinum), and malignant small round cell tumor (mostly in chest wall). Most patients were presented by fever (21.5%), dyspnea (20%)and cough (12%), especially in Hodgkin’s and non-Hodgkin’s lymphoma. Lymphadenopathy(29.2%) and hepatosplenomegaly (13.8%) were the most frequent clinical signs. Laboratory examination revealed anemia (29%), leukocytosis (35%), and high sedimentation rate(21.5%). Conclusion: The clinical presentation and laboratory findings of mediastinal and chest wall masses are often non-specific and are variable, but according to their clinical data (i.e. age) and location, only few important diagnoses should be considered.
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Authors
Mitra Mehrazma
Department of Pathology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
Soraya Salehi
Department of Pediatrics, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
Shokrollah Yousefi
Department of Pathology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
Selaheddin Delshad
Department of Surgery, School of Medicine, Iran University of Medical Sciences, Tehran, Iran