DEVELOPMENT OF DUAL RESPONSIVE NANOMAGNETIC FOR DELIVERY OF ANTICANCER DRUGS
Publish place: The third national conference on new technologies in the chemical, petrochemical and Iran Nanotechnology
Publish Year: 1395
نوع سند: مقاله کنفرانسی
زبان: English
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شناسه ملی سند علمی:
TCPCO03_107
تاریخ نمایه سازی: 16 شهریور 1395
Abstract:
A new two-step route for the preparation of nano-scaled magnetic chitosan particles has been developed, different from reported one-step in situ preparation and two-step preparation method of reversed-phase suspension, Triton X-100 reversed-phase water-in-oil microemulsion encapsulation method was employed in coating the pre-prepared Fe3O4 nanoparticles with chitosan. Two model anticancer drugs, Doxorubicin (DOX) and Methotrexate (MTX) were loaded effectively to functionalized MNPs through electrostatic interactions. Our developed UV method was applied for simultaneous determination of DOX and MTX. It was concluded that our findings may open the possibilities for pH-responsive targeted delivery of DOX and MTX to the cancerous tissues
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Authors
R Najjar
Polymer Research Laboratory, Faculty of Chemistry, University of Tabriz, Tabriz, Iran
Sh Moradi
Polymer Research Laboratory, Faculty of Chemistry, University of Tabriz, Tabriz, Iran.
H Hamishehkar
Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran