Central interaction of ascorbic acid and D2 dopamine receptors on spatial learning and memory in adult male rats

Publish Year: 1393
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:

JR_IJVST-6-1_004

تاریخ نمایه سازی: 11 تیر 1396

Abstract:

Previous studies had reported that extracellular levels of ascorbic acid have modulatory effects on dopamine receptors. Both ascorbic acid and dopamine receptor have an important role in learning and memory processes. However, the central interaction between ascorbic acid and dopamine D2 receptor on spatial learning and memory has not yet been elucidated. All experiments were carried out on male Wistar rats. Animals were subjected to 5 days of training in the Morris water maze (MWM) task; 4 days with an invisible platform to test special learning and the 5th day with a visible platform to test motivation and sensorimotor coordination. The data showed that ascorbic acid (25 μg, i.c.v.) could improve spatial learning and memory indices. Administration of bromocriptine, a D2 agonist, increased the effect of ascorbic acid, while treatment with the selective D2 antagonist sulpiride resulted in prevention of the ascorbate-induced memory consolidation. These results indicate that dopamine D2 receptors may be involved in ascorbic acid-induced learning and memory impairment

Authors

Sima Nasri

Department of Biology, Faculty of Sciences, Payam Noor University of Tehran, Tehran, Iran

Mehri Bahaaddini

Taalim and tarbiat College of Kerman,Kerman, Iran

Mehdi Abbasnejad

Department of Biology, Faculty of Sciences, Shahid Bahonar University of Kerman, Kerman, Iran

Saeed Esmaeili-Mahani

Department of Biology, Faculty of Sciences, Shahid Bahonar University of Kerman, Kerman, Iran